Recommendations for the diagnosis and treatment of bone marrow form of acute radiation syndrome

Introduction. Only a massive radiation accident, and not individual incidents heterogeneous in terms of exposure conditions, contributes to the revision development knowledge therapeutic capabilities acute syndrome (ARS). Aim — present recommendations based on literature data own clinical experience for diagnosis treatment typical bone marrow form ARS from relatively uniform irradiation. General information. An analysis problem was carried out, providing medical care victims April 26, 1986 accident at Chernobyl Nuclear Power Plant (104 patients with OLB) department A.I. Burnazyan State Medical Center FMBA Russia is summarized. When admitting individuals involved into institution, one most important measures action conduct sorting, that is, distribution groups according principle need homogeneous therapeutic, preventive evacuation measures, depending indications, specific conditions situation prognosis patient's survival dose assessment prediction severity course by all available methods physical biological dosimetry (calculation method, simulation situation, signs primary reaction radiation, cytogenetic absolute number peripheral blood lymphocytes during first 8 days after irradiation, dynamics neutrophils, etc.). The scope depends developing ARS, including therapy infectious complications hemorrhagic syndrome. appointment myelostimulation order reduce depth duration radiation-induced cytopenia recommended when irradiated more than 1.5 Gy. Transplantation allogeneic hematopoietic stem cells narrow range 10 13 Gy absence concomitant severe injuries burns. Recommendations oropharyngeal intestinal syndromes are given.